Abstract:

In the development of various ocular diseases, the immune response mediated by macrophages and inflammatory cytokine is important in the pathogenesis. Under the effect of microenvironment signals, macrophages could polarize to M1 or M2 macrophages with different cytokines, receptor expression, and functions. Macrophages are versatile and heterogeneous cells that could undergo their phenotypically/functionally dynamic. Macrophage polarization was involved in the pathogenesis of the corneal disease, age-related macular degeneration, diabetic retinopathy and autoimmune uveitis,  and the plasticity of macrophage make it possible to be an ideal target for therapy.